G6PD: A hub for metabolic reprogramming and redox signaling in cancer

Metabolic hubs play a major role in the initiation and development of cancer. Oncogenic signaling pathways drive metabolic reprogramming and alter redox homeostasis. G6PD has potential oncogenic activity and it plays a pivotal role in cell proliferation, survival and stress responses. Aberrant activation of G6PD via metabolic reprogramming alters NADPH levels, leading to an antioxidant or a pro-oxidant environment which can either enhance DNA oxidative damage and genomic instability or initiate oncogenic signaling. Nutrient deprivation can rewire metabolism, which leads to mutations that determine a cancer cell's fate. Deregulated G6PD status and oxidative stress form a vicious cycle, which paves the way for cancer progression. This review aims to update and focus the potential role of G6PD in metabolic reprogramming and redox signaling in cancer.

Automated summary

Metabolic hubs are crucial in cancer initiation and development. G6PD, a pivotal factor, affects cell proliferation and survival through altering redox homeostasis. The aberrant activation of G6PD via metabolic reprogramming can lead to either oxidative damage or oncogenic signaling in cancer cells.