期刊
INSECTS
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/insects11070406
关键词
small non-coding RNA; piRNA; small RNAs; mosquito reproduction
类别
资金
- NIH [U54 HD 090216, COBRE 5P20GM104936-10, S10OD021743]
Malaria is a major global health problem, where the anautogenous female mosquitoAnopheles gambiaeserves as a major vector. In order to combat this devastating disease, understanding mosquito physiology is paramount. Numerous studies in the vector field demonstrate that small non-coding RNAs (ncRNAs) play essential roles in numerous aspects of mosquito physiology. While our previous miRNA annotation work demonstrated expression dynamics across differing tissues, miRNAs represented less than 20% of all small ncRNAs in our small RNA-Seq libraries. To this end, we systematically classified multiple small ncRNA groups across mosquito tissues. Here we (i) determined a new enriched-midgut miRNA, (ii) updated the piRNA annotation in ovaries with a genomic map of unique-mapping piRNAs, (iii) identified pan-tissue and tissue-enriched mRNA-derived small ncRNAs, and (iv) assessed AGO1- and AGO2- loading of candidate small ncRNAs. Continued research will broaden our view of small ncRNAs and greatly aide in our understanding on how these molecules contribute to mosquito physiology.
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