期刊
GASTROENTEROLOGY REPORT
卷 8, 期 3, 页码 215-223出版社
OXFORD UNIV PRESS
DOI: 10.1093/gastro/goaa025
关键词
beta beta-catenin; cancer stem cells; metabolic reprogramming; metabolism; PGAM5
资金
- National Institutes of Health [R01-DK117001]
- Litwin IBD Pioneers Crohn's Colitis Foundation [391869]
Mitochondria are dynamic organelles that play a key role in integrating cellular signaling. Mitochondrial alterations are evident in all stages of tumorigenesis and targeting mitochondrial pathways has emerged as an anticancer therapeutic strategy. The Wnt-signaling pathway regulates many fundamental cellular functions such as proliferation, survival, migration, stem-cell maintenance, and mitochondrial metabolismand dynamics. Emerging evidence demonstrates that mitochondrial-induced regulation of Wnt signaling provides an additional mechanism to influence cell-fate decisions. Crosstalk between mitochondria and Wnt signaling presents a feedforward loop in which Wnt activation regulates mitochondrial function that, in turn, drives Wnt signaling. In this mini-review, we will discuss the recent evidence revealing the mitochondrial control of Wnt signaling and its implications for tumorigenesis and anticancer therapeutic targeting.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据