期刊
JOURNAL OF ADVANCED RESEARCH
卷 26, 期 -, 页码 149-159出版社
ELSEVIER
DOI: 10.1016/j.jare.2020.08.002
关键词
COVID-19; Clinical sensitivity; In vitro diagnostics; Real-time RT-PCR; Point-of-care; SARS-CoV-2
资金
- Deanship of Scientific Research, University of Hafr Al Batin [G-107-2020]
Background: To curb the spread of the COVID-19 (coronavirus disease 2019) pandemic, the world needs diagnostic systems capable of rapid detection and quantification of the novel coronavirus (SARS-CoV-2). Many biomedical companies are rising to the challenge and developing COVID-19 diagnostics. In the last few months, some of these diagnostics have become commercially available for healthcare workers and clinical laboratories. However, the diagnostic technologies have specific limitations and reported several false-positive and false-negative cases, especially during the early stages of infection. Aim: This article aims to review recent developments in the field of COVID-19 diagnostics based on molecular technologies and analyze their clinical performance data. Key Concepts: The literature survey and performance-based analysis of the commercial and precommercial molecular diagnostics address several questions and issues related to the limitations of current technologies and highlight future research and development challenges to enable timely, rapid, low-cost, and accurate diagnosis of emerging infectious diseases. (C) 2020 The Author. Published by Elsevier B.V. on behalf of Cairo University.
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