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CELL STEM CELL (2007)
Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes
Jonghyeob Lee et al.
DEVELOPMENT (2007)
Phenotypic characterization of human colorectal cancer stem cells
Piero Dalerba et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Activated Notch1 interacts with p53 to inhibit its phosphorylation and transactivation
S. B. Kim et al.
CELL DEATH AND DIFFERENTIATION (2007)
Novel cell culture technique for primary ductal carcinoma in situ: Role of notch and epidermal growth factor receptor signaling pathways
Gillian Farnie et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2007)
The Hes gene family: repressors and oscillators that orchestrate embryogenesis
Ryoichiro Kageyama et al.
DEVELOPMENT (2007)
Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKα kinases
Karine Lefort et al.
GENES & DEVELOPMENT (2007)
Delta-like ligand 4 (DII4) is induced by VEGF as a negative regulator of angiogenic sprouting
I. B. Lobov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Identification of pancreatic cancer stem cells
Chenwei Li et al.
CANCER RESEARCH (2007)
Activation of Notch signaling in tumorigenesis of experimental pancreatic cancer induced by dimethylbenzanthracene in mice
Kenji Kimura et al.
CANCER SCIENCE (2007)
Identification and expansion of human colon-cancer-initiating cells
Lucia Ricci-Vitiani et al.
NATURE (2007)
Mammary stem cells and breast cancer - Role of notch signalling
Gillian Farnie et al.
STEM CELL REVIEWS (2007)
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
Irene Noguera-Troise et al.
NATURE (2006)
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
John Ridgway et al.
NATURE (2006)
A complex oscillating network of signaling genes underlies the mouse segmentation clock
Mary-Lee Dequeant et al.
SCIENCE (2006)
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch- dependent ubiquitination
Lucia Di Marcotullio et al.
NATURE CELL BIOLOGY (2006)
High levels of Notch signaling down-regulate Numb and Numblike
Gavin Chapman et al.
JOURNAL OF CELL BIOLOGY (2006)
Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis
Soline Estrach et al.
DEVELOPMENT (2006)
Canonical Notch signaling functions as a commitment switch in the epidermal lineage
Cedric Blanpain et al.
GENES & DEVELOPMENT (2006)
Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias
T. Palomero et al.
LEUKEMIA (2006)
Impaired Notch signaling promotes de novo squamous cell carcinoma formation
Aaron Proweller et al.
CANCER RESEARCH (2006)
Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors
Xing Fan et al.
CANCER RESEARCH (2006)
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor
MA Esteban et al.
CANCER RESEARCH (2006)
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
HS Phillips et al.
CANCER CELL (2006)
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B
B Krishnamachary et al.
CANCER RESEARCH (2006)
Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma
D Massi et al.
MODERN PATHOLOGY (2006)
Notch signalling in vertebrate neural development
A Louvi et al.
NATURE REVIEWS NEUROSCIENCE (2006)
Evidence that stem cells reside in the adult Drosophila midgut epithelium
CA Micchelli et al.
NATURE (2006)
The adult Drosophila posterior midgut is maintained by pluripotent stem cells
B Ohlstein et al.
NATURE (2006)
Activating Notch1 mutations in mouse models of T-ALL
J O'Neil et al.
BLOOD (2006)
Activation of Notch1 signaling is required for β-catenin-mediated human primary melanoma progression
K Balint et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma
K Somasundaram et al.
ONCOGENE (2005)
Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells
CL Curry et al.
ONCOGENE (2005)
High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
M Reedijk et al.
CANCER RESEARCH (2005)
The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis
D Luo et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2005)
Identification of bronchioalveolar stem cells in normal lung and lung cancer
CFB Kim et al.
CELL (2005)
Notch signals control the fate of immature progenitor cells in the intestine
S Fre et al.
NATURE (2005)
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
JH van Es et al.
NATURE (2005)
Notch signaling in the mammalian central nervous system: insights from mouse mutants
K Yoon et al.
NATURE NEUROSCIENCE (2005)
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
IM Conboy et al.
NATURE (2005)
Induction of apoptosis by proteasome inhibitors in B-CLL cells is associated with downregulation of CD23 and inactivation of Notch2
M Duechler et al.
LEUKEMIA (2005)
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
DJ Manalo et al.
BLOOD (2005)
Notch signaling: control of cell communication and cell fate
EC Lai
DEVELOPMENT (2004)
Cancer stem cells in nervous system tumors
SK Singh et al.
ONCOGENE (2004)
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
LD Walensky et al.
SCIENCE (2004)
Modulation of notch signaling elicits signature tumors and inhibits Hras1-induced oncogenesis in the mouse mammary epithelium
H Kiaris et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas
K Hoek et al.
CANCER RESEARCH (2004)
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation
LA Timmerman et al.
GENES & DEVELOPMENT (2004)
Modulation of notch processing by γ-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation
J Milano et al.
TOXICOLOGICAL SCIENCES (2004)
Notch1 and Notch2 have opposite effects on embryonal brain tumor growth
X Fan et al.
CANCER RESEARCH (2004)
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
AP Weng et al.
SCIENCE (2004)
JAGGED1 expression is associated with prostate cancer metastasis and recurrence
S Santagata et al.
CANCER RESEARCH (2004)
Notch in mammary gland development and breast cancer
K Politi et al.
SEMINARS IN CANCER BIOLOGY (2004)
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
G Dontu et al.
BREAST CANCER RESEARCH (2004)
Cancerous stem cells can arise from pediatric brain tumors
HD Hemmati et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
SR Hingorani et al.
CANCER CELL (2003)
Osteoblastic cells regulate the haematopoietic stem cell niche
LM Calvi et al.
NATURE (2003)
Glycosylation regulates notch signalling
N Haines et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Alterations in signal transduction pathways implicated in tumour progression during multistage mouse skin carcinogenesis
V Zoumpourlis et al.
CARCINOGENESIS (2003)
Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis
Y Miyamoto et al.
CANCER CELL (2003)
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development
T Saito et al.
IMMUNITY (2003)
Notch1 functions as a tumor suppressor in mouse skin
M Nicolas et al.
NATURE GENETICS (2003)
Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage
HS Yoon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
AM Kenney et al.
DEVELOPMENT (2003)
Asymmetric segregation of Numb:: a mechanism for neural specification from Drosophila to mammals
M Cayouette et al.
NATURE NEUROSCIENCE (2002)
Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells
S Weijzen et al.
NATURE MEDICINE (2002)
The endocytic protein α-adaptin is required for numb-mediated asymmetric cell division in Drosophila
D Berdnik et al.
DEVELOPMENTAL CELL (2002)
Expression profiling of cancer-related genes in human keratinocytes following non-lethal ultraviolet B irradiation
T Murakami et al.
JOURNAL OF DERMATOLOGICAL SCIENCE (2001)
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
A Rangarajan et al.
EMBO JOURNAL (2001)
Isolation of invasion-associated cDNAs in melanoma
A Gütgemann et al.
ARCHIVES OF DERMATOLOGICAL RESEARCH (2001)
Chromosome 19 translocation, overexpression of Notch3, and human lung cancer
TP Dang et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)
Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays
C Leethanakul et al.
ONCOGENE (2000)
Keratinocyte growth factor signalling: a mathematical model of dermal-epidermal interaction in epidermal wound healing
HJ Wearing et al.
MATHEMATICAL BIOSCIENCES (2000)
Lateral induction by juxtacrine signaling is a new mechanism for pattern formation
MR Owen et al.
DEVELOPMENTAL BIOLOGY (2000)
Control sf endodermal endocrine development by Hes-1
J Jensen et al.
NATURE GENETICS (2000)
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