期刊
CELLS
卷 9, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/cells9071687
关键词
Parkinson's disease; neuroinflammation; immune system; therapy; neurodegeneration
类别
资金
- Spanish Ministry of Economy and Competiveness [PID2019-110061RB-I00, SAF2017-82436R]
- Spanish Tatiana de Guzman el Bueno Foundation [P-024-FTPGB 2018]
- European Regional Development Fund, Competitiveness Operational Program 2014-2020 [P_37_732/2016]
- Comunidad Autonoma de Madrid [B2017/BMD-3827, S2017-BMD-3686]
- contract Juan de la Cierva (MICINN)
Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized by the death of dopaminergic neurons that project from the substantia nigrapars compacta. Although the molecular bases for PD development are still little defined, extensive evidence from human samples and animal models support the involvement of inflammation in onset or progression. However, the exact trigger for this response remains unclear. Here, we provide a systematic review of the cellular mediators, i.e., microglia, astroglia and endothelial cells. We also discuss the genetic and transcriptional control of inflammation in PD and the immunomodulatory role of dopamine and reactive oxygen species. Finally, we summarize the preclinical and clinical approaches targeting neuroinflammation in PD.
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