期刊
CELLS
卷 9, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/cells9061404
关键词
HBV; glycosylation; folding; vaccine; immune response; HCC
类别
资金
- EEA Grants 2014-2021
- SmartVac Project [1/2019]
- Ministry of Research and Innovation, CNCS-UEFISCDI [PN-III-P1-1.1-TE-2016-1894]
Hepatitis B Virus (HBV) glycobiology has been an area of intensive research in the last decades and continues to be an attractive topic due to the multiple roles that N-glycosylation in particular plays in the virus life-cycle and its interaction with the host that are still being discovered. The three HBV envelope glycoproteins, small (S), medium (M) and large (L) share a very peculiar N-glycosylation pattern, which distinctly regulates their folding, degradation, assembly, intracellular trafficking and antigenic properties. In addition, recent findings indicate important roles of N-linked oligosaccharides in viral pathogenesis and evasion of the immune system surveillance. This review focuses on N-glycosylation's contribution to HBV infection and disease, with implications for development of improved vaccines and antiviral therapies.
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