期刊
CANCERS
卷 12, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/cancers12061659
关键词
p53 isoforms; Delta 40p53; p53; cancer; aging
类别
资金
- Cancer Institute NSW [CDF181205]
- University of Newcastle International Postgraduate Research Scholarship
- CINSW-Hunter Cancer Research Alliance PhD Scholarship
- Iwanowska Programme, The Polish National Agency for Academic Exchange [PPN/IWA/2018/1/00005]
The tumour suppressor p53 is essential for maintaining DNA integrity, and plays a major role in cellular senescence and aging. Understanding the mechanisms that contribute to p53 dysfunction can uncover novel possibilities for improving cancer therapies and diagnosis, as well as cognitive decline associated with aging. In recent years, the complexity of p53 signalling has become increasingly apparent owing to the discovery of the p53 isoforms. These isoforms play important roles in regulating cell growth and turnover in response to different stressors, depending on the cellular context. In this review, we focus on Delta 40p53, an N-terminally truncated p53 isoform. Delta 40p53 can alter p53 target gene expression in both a positive and negative manner, modulating the biological outcome of p53 activation; it also functions independently of p53. Therefore, proper control of the Delta 40p53: p53 ratio is essential for normal cell growth, aging, and responses to cancer therapy. Defining the contexts and the mechanisms by which Delta 40p53 behaves as a good cop or bad cop is critical if we are to target this isoform therapeutically.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据