期刊
SCIENCE ADVANCES
卷 6, 期 28, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aba5855
关键词
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资金
- Zukunftskonzept of the TU Dresden under the Excellence Initiative of the German Science Foundation (DFG)
- Netherlands Organization for Scientific Research (Innovational Research Incentives Scheme-VIDI: SAMURAI project) [14855]
- National Science Foundation [CMMI-1635443]
- German Research Foundation [SPP 1726]
- European Union's Horizon 2020 research and innovation program [835268, 853609]
- Leibniz Program of the German Research Foundation [SCHM 1298/26-1]
- Freigeist fellowship from Volkswagen Foundation [91619]
We develop biohybrid magnetic microrobots by electrostatic self-assembly of nonmotile sperm cells and magnetic nanoparticles. Incorporating a biological entity into microrobots entails many functional advantages beyond shape templating, such as the facile uptake of chemotherapeutic agents to achieve targeted drug delivery. We present a single-step electrostatic self-assembly technique to fabricate IRONSperms, soft magnetic microswimmers that emulate the motion of motile sperm cells. Our experiments and theoretical predictions show that the swimming speed of IRONSperms exceeds 0.2 body length/s (6.8 +/- 4.1 mu m/s) at an actuation frequency of 8 Hz and precision angle of 45 degrees. We demonstrate that the nanoparticle coating increases the acoustic impedance of the sperm cells and enables localization of clusters of IRONSperm using ultrasound feedback. We also confirm the biocompatibility and drug loading ability of these microrobots, and their promise as biocompatible, controllable, and detectable biohybrid tools for in vivo targeted therapy.
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