期刊
SCIENCE ADVANCES
卷 6, 期 31, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abc5801
关键词
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资金
- NIH [RO11DC016222, U19 NS112953, P30NS072030, RO1DC007235]
- Simons Collaboration on the Global Brain
- NSF
- Programma per Giovani Ricercatori Rita Levi Montalcini, Italian Ministry of Education, University, and Research
- Research Foundation Flanders (FWO) [1246220N]
- Gordon and Betty Moore Foundation [GBMF3834]
- Alfred P. Sloan Foundation [2013-10-27]
- Leverhulme Trust [RPG-2016-095]
- European Research Council [725729]
- Medical Research Council [K013807]
- Medical Research Council Clinical Infrastructure Award [M008924]
- BBSRC [BB/P022073/1]
- BBSRC National Capability in Genomics and Single Cell Analysis at Earlham Institute [BB/CCG1720/1]
- [R01DC016859]
- [R01DC014423]
- [R01DC016224]
- BBSRC [BB/P022073/1] Funding Source: UKRI
- European Research Council (ERC) [725729] Funding Source: European Research Council (ERC)
Altered olfactory function is a common symptom of COVID-19 (coronavirus disease 2019), but its etiology is unknown. A key question is whether SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2; CoV-2)-the causal agent in COVID-19-affects olfaction directly, by infecting olfactory sensory neurons or their targets in the olfactory bulb, or indirectly, by perturbing support cells. Bulk and single-cell RNA sequencing revealed that support and stem cells in the human and mouse olfactory epithelium and vascular pericytes in the mouse olfactory bulb express angiotensin-converting enzyme 2 (ACE2), which is essential for CoV-2 cell entry. In contrast, ACE2 was not detected in either olfactory sensory neurons or olfactory bulb neurons. Immunostaining confirmed these results and revealed pervasive expression of ACE2 protein in dorsally located olfactory epithelial sustentacular cells and mouse olfactory bulb pericytes. These findings suggest that CoV-2 infection of non-neuronal cell types leads to olfactory dysfunction in patients with COVID-19.
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