期刊
CHEM
卷 6, 期 8, 页码 1877-1887出版社
CELL PRESS
DOI: 10.1016/j.chempr.2020.07.007
关键词
-
资金
- Max-Planck-Institut fur Kohlenforschung
The term late-stage functionalization (LSF) is recent but is now frequently used in the field of organic methodology development to describe transformations on complex molecules. Such reactions include catalytic and non-catalytic reactions, C-H functionalizations, and functional-group manipulations with one or several desired products. However, explicit guidance to classify whether a reaction is a LSF or not, and why or why not, is not available. Herein, we advance a definition for LSF and highlight the requirements, features, and challenges of LSF reactions accompanied by representative examples. We aspire that our analysis will be helpful as a guiding principle in the field.
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