期刊
CHEMISTRYSELECT
卷 5, 期 26, 页码 7901-7908出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202001230
关键词
Electron microscopy; gold; Pimenta dioica; photoacoustic signal response; photothermal therapy
资金
- Indian Council of Medical Research (ICMR), India [ICMR35/6/2019-Nano/BMS]
- Department of Science and Technology (DST), Government of India [DST/INSPIRE Fellowship/2016/IF160865, DST/INSPIRE Fellowship/2014/IF140809]
In recent years, gold nanoparticles have emerged as promising agents for plasmonic sensing, photoacoustic imaging, photothermal therapy, and other biomedical applications. In this work, green synthesis of plant-mediated gold nanoparticles (AuNPs) using an aqueous leaf extract ofPimenta dioicawas carried out and the synthesized nanoparticles were characterized using X-ray diffraction (XRD), ultraviolet-visible (UV-Vis) absorption spectroscopy, Fourier transform infra-red (FTIR) spectroscopy, and electron microscopy. A plausible mechanism of the formation of gold nanoparticles fromPimenta dioicaleaf extract was also proposed. Synthesized AuNPs were found to be safe for human cervical cancer (HeLa) and human embryonic kidney 293 (HEK 293) cell lines established using MTT (3-(4,5-dimethylthiozol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. The potential of the synthesized nanoparticles for the plasmonic sensing of analyte molecule was carried out using the AuNPs as a surface-enhanced Raman spectroscopy substrate. It was found that the AuNPs enhanced the Raman signal of analyte molecules with an enhancement factor of >10(5)in comparison to the normal Raman signal measured from the analyte, i. e., without nanoparticles. Further, the synthesized AuNPs showed excellent photoacoustic signal responses (PASR) and found to be the most efficient photoacoustic signal generators. The photothermal performance of these nanoparticles was also carried out. Overall, the findings of this study suggest that in future, these AuNPs could be used as a green alternative to conventionally used in-vivo theranostic agents.
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