期刊
CHEMISTRYSELECT
卷 5, 期 23, 页码 6861-6893出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202000764
关键词
Acylation; Alkylation; Benzylation; Carbamate; Formylation; N-protection; Peptide synthesis
资金
- UGC-CAS
Selective protection of -NH(2)functionality has enormous utility and significance in organic synthesis. Amines are nucleophile and basic in nature thus vulnerable to react with an extensive range of reagents, especially oxidizing, alkylating, and carbonyl compounds and therefore can require protection to mask these properties in the multifunctional molecule during chemical reactions. Protection of amine functionality finds important application in peptide synthesis, thus several methodologies have been developed for N-Protection reaction. Herein, we have reviewed recent advances in the protection of amines (from 2012 till present) in the hope that this will update the current body of knowledge and aid researchers working in this area.
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