期刊
FOOD BIOSCIENCE
卷 36, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fbio.2020.100599
关键词
Mauritia flexuosa; Euterpe oleracea; Theobroma grandiflorum; Inflammatory bowel disease; Polyphenol; Short-chain fatty acid
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil [15/15267-8]
- National Council for Scientific and Technology Development (CNPq -Brazilian Ministry of Science and Technology), Brazil
- Coordination for the Improvement of Higher Education Personnel (CAPES, Brazilian Ministry of Education), Brazil
Dietary products with prebiotic and antioxidant properties may be used to protect against chronic diseases, including inflammatory bowel diseases. Assai berry, burity palm and cupuassu from the Amazon are functional foods because of their high level of dietary fiber and polyphenols, which have an important role in the prevention of inflammatory processes. Their activity as a dietary supplement was measured using fruit pulp flours in a trinitrobenzenesulphonic acid model of intestinal inflammation. The intestinal anti-inflammatory effects were evaluated using clinical parameters and biochemical analysis of pro-inflammatory cytokines (IL-6, IL-1 beta and TNF-alpha), whereas antioxidant activity was studied using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, mieloperoxidase (MPO) and alkaline phosphatase (ALP) activities, glutathione (GSH) level and phenolic content. The effects of dietary supplementation on the mucin release and short-chain fatty acid (SCFA) production were studied. Assai berry and burity palm reduced MPO and ALP activities, counteracted GSH and propionate reductions induced by the inflammatory process as well as decreased IL-6, IL-1 beta and TNF-alpha levels and increased mucin production. Cupuassu reduced MPO and ALP activities, IL-6 and IL-1 beta levels and increased colonic mucin, without effects on the SCFA production and TNF-alpha colonic level. In vitro studies showed the antioxidant properties, which were associated with the presence of polyphenol compounds and scavenging activity using the DPPH assay. The results indicated the possible benefits of using assai berry and burity palm fruits as dietary antioxidant, prebiotic, immune modulators and anti-inflammatory complementary products to treat intestinal inflammation.
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