期刊
FRONTIERS IN PEDIATRICS
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fped.2020.00355
关键词
kawasaki disease; infectious disease; vasculitis; coronary aneurysm; biomarker; bacterial infection; viral infection
类别
资金
- European Seventh Framework Program for Research and Technological Development (FP7) under EUCLIDS [279185]
- European Union [668303]
- STINAFO
- Sanquin Blood Supply Product and Process Development Cellular Products Fund [PPOC 1957]
- UKRI [MR/S032304/1] Funding Source: UKRI
Background:Kawasaki disease (KD) is a vasculitis of early childhood mimicking several infectious diseases. Differentiation between KD and infectious diseases is essential as KD's most important complication-the development of coronary artery aneurysms (CAA)-can be largely avoided by timely treatment with intravenous immunoglobulins (IVIG). Currently, KD diagnosis is only based on clinical criteria. The aim of this study was to evaluate whether routine C-reactive protein (CRP) and additional inflammatory parameters myeloid-related protein 8/14 (MRP8/14 or S100A8/9) and human neutrophil-derived elastase (HNE) could distinguish KD from infectious diseases. Methods and Results:The cross-sectional study included KD patients and children with proven infections as well as febrile controls. Patients were recruited between July 2006 and December 2018 in Europe and USA. MRP8/14, CRP, and HNE were assessed for their discriminatory ability by multiple logistic regression analysis with backward selection and receiver operator characteristic (ROC) curves. In the discovery cohort, the combination of MRP8/14+CRP discriminated KD patients (n= 48) from patients with infection (n= 105), with area under the ROC curve (AUC) of 0.88. The HNE values did not improve discrimination. The first validation cohort confirmed the predictive value of MRP8/14+CRP to discriminate acute KD patients (n= 26) from those with infections (n= 150), with an AUC of 0.78. The second validation cohort of acute KD patients (n= 25) and febrile controls (n= 50) showed an AUC of 0.72, which improved to 0.84 when HNE was included. Conclusion:When used in combination, the plasma markers MRP8/14, CRP, and HNE may assist in the discrimination of KD from both proven and suspected infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据