期刊
FRONTIERS IN ENDOCRINOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2020.00498
关键词
thermogenic fat; brown adipocyte; beige adipocyte; adipogenesis; uncoupling protein 1
资金
- AMED [JP19gm6210011]
- JSPS KAKENHI [19K23745]
- Boehringer/Lilly Diabetes Research Grant in Japan Diabetes Foundation
- 2020 Inamori Research Grant Program
- Naito Foundation
- Ono Medical Research Foundation
- Novartis Foundation(Japan) for the Promotion of Science
- Uehara Memorial Foundation
- MSD Life Science Foundation
- Public Interest Incorporated Foundation
- Astellas Foundation for Research on Metabolic Disorders
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Kanae Foundation for the Promotion of Medical Science
- Ichiro Kanehara Foundation
- Grants-in-Aid for Scientific Research [19K23745] Funding Source: KAKEN
Mammals have two types of thermogenic adipocytes: brown adipocytes and beige adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to dissipates energy in the form of heat by uncoupling the mitochondrial proton gradient from mitochondrial respiration. There is much evidence that UCP1 is the center of BAT thermogenesis and systemic energy homeostasis. Recently, UCP1 independent thermogenic pathway identified in thermogenic adipocytes. Importantly, the thermogenic pathways are different in brown and beige adipocytes. Ca2+-ATPase 2b calcium cycling mechanism is selective to beige adipocytes. It remains unknown how the multiple thermogenic mechanisms are coordinately regulated. The discovery of UCP1-independent thermogenic mechanisms potential offer new opportunities for improving obesity and type 2 diabetes particularly in groups such as elderly and obese populations who do not possess UCP1 positive adipocytes.
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