期刊
FRONTIERS IN GENETICS
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2020.00554
关键词
Candida; haemulonii; duobushaemulonii; pseudohaemulonii; vulturna
资金
- National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [U19AI110818]
The recent emergence of a multidrug-resistant yeast,Candida auris, has drawn attention to the closely related species from theCandida haemuloniicomplex that includeC. haemulonii, Candida duobushaemulonii, Candida pseudohaemulonii, and the recently identifiedCandida vulturna. Here, we used antifungal susceptibility testing and whole-genome sequencing (WGS) to investigate drug resistance and genetic diversity among isolates ofC. haemuloniicomplex from different geographic areas in order to assess population structure and the extent of clonality among strains. Although most isolates of all four species were genetically distinct, we detected evidence of the in-hospital transmission ofC. haemuloniiandC. duobushaemuloniiin one hospital in Panama, indicating that these species are also capable of causing outbreaks in healthcare settings. We also detected evidence of the rising azole resistance among isolates ofC. haemuloniiandC. duobushaemuloniiin Colombia, Panama, and Venezuela linked to substitutions inERG11gene as well as amplification of this gene inC. haemuloniiin isolates in Colombia suggesting the presence of evolutionary pressure for developing azole resistance in this region. Our results demonstrate that these species need to be monitored as possible causes of outbreaks of invasive infection.
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