期刊
FRONTIERS IN CHEMISTRY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2020.00682
关键词
maghemite; cerium oxide; nanoparticles; oxidative stress; antioxidant
资金
- Czech Science Foundation [20-02177J]
- Ministry of Health of the Czech Republic under the Conceptual Development of Research Organizations program (Institute for Clinical and Experimental Medicine - IKEM) [IN 00023001]
- Ministry of Education, Youth and Sports of Czech Republic within the National Sustainability Program II [BIOCEV-FAR LQ1604]
- CSF [20-08679S]
Magnetic gamma-Fe2O3/CeO(x)nanoparticles were obtained by basic coprecipitation/oxidation of iron chlorides with hydrogen peroxide, followed by precipitation of Ce(NO3)(3)with ammonia. The appearance of CeO(x)on the magnetic particle surface was confirmed by X-ray photoelectron spectroscopy (XPS), powder X-ray diffraction (XRD), and elemental analysis; a magnetometer was used to measure the magnetic properties of gamma-Fe2O3/CeOx. The relatively high saturation magnetization of the particles (41.1 A center dot m(2)/kg) enabled magnetic separation. The surface of gamma-Fe2O3/CeO(x)particles was functionalized with PEG-neridronate of two different molecular weights to ensure colloidal stability and biocompatibility. The ability of the particles to affect oxidative stress in hereditary hypertriglyceridemic (HHTg) rats was tested by biological assay of the liver, kidney cortex, and brain tissues. An improvement was observed in both enzymatic [superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)] and non-enzymatic (reduced (GSH) and oxidized (GSSG) glutathione) levels of antioxidant defense and lipid peroxidation parameters [4-hydroxynonenal (4-HNE) and malondialdehyde (MDA)]. The results corresponded with chemical determination of antioxidant activity based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, proving that in the animal model gamma-Fe2O3/CeOx@PEG(2,000)nanoparticles effectively scavenged radicals due to the presence of cerium oxide, in turn decreasing oxidative stress. These particles may therefore have the potential to reduce disorders associated with oxidative stress and inflammation.
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