期刊
MATERIALS & DESIGN
卷 193, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.matdes.2020.108805
关键词
PLGA-lipid hybrid nanocartiers; Gene transfection; Nontoxidty; Multifunctional carriers; Clinical trial
资金
- Operational Programme Human Capital of the Ministry of European Funds [51668/09.07.2019, 124705]
- Ministry of Research and Innovation, CNCS -UEFISCDI within PNCDI III [PN-III-P4ID-PCE-2016-0818]
The concept of PLGA-lipid hybrid nanopartides arose as a motivation for developing drug delivery systems with versatile physical and chemical properties, unequivocal therapeutic benefits and minimized side effects. These formulations opened a new avenue of smart tools in the development of personalized, noninvasive emerging nanomedicine. However, there is still the risk that smart hybrid system manufactured from a mixture of materials, such as PLGA in combination with synthetic/vegetable lipids and targeting agents might trigger high nanotoxicological responses. This review is focused on the detailed description of PLGA-lipids/oils hybridization concept and its effect on the performances of nanocarriers as powerful, versatile delivery system, the manufacturing methods, the main applications, and their potential clinical impact. The successful design of a hybrid formulation involves two foremost challenges, firstly a comprehensive consideration of essential characteristics of each constituent that form the hybrid system and secondly, a deep understanding of the interactions of hybrid nanocarrier with cells in order to predict the potential toxicity issues and ensure its safe clinical applications. (C) 2020 The Authors. Published by Elsevier Ltd.
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