期刊
MYCOTOXIN RESEARCH
卷 36, 期 4, 页码 389-397出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s12550-020-00404-w
关键词
Zearalanone; Zearalanols; Zearalenone-14-sulfate; Zearalenone-14-glucoside; Serum albumin; Species differences
资金
- Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences
- Janos Laszlo Doctoral Student Research Scholarship
The xenoestrogenic mycotoxin zearalenone is aFusarium-derived food and feed contaminant. In mammals, the reduced (e.g., zearalanone, alpha-zearalanol, and beta-zearalanol) and conjugated (e.g., zearalenone-14-sulfate) metabolites of zearalenone are formed. Furthermore, filamentous fungi and plants are also able to convert zearalenone to conjugated derivatives, including zearalenone-14-sulfate and zearalenone-14-glucoside, respectively. Serum albumin is the dominant plasma protein in the circulation; it interacts with certain mycotoxins, affecting their toxicokinetics. In a previous investigation, we demonstrated the remarkable species differences regarding the albumin binding of zearalenone and zearalenols. In the current study, the interactions of zearalanone, alpha-zearalanol, beta-zearalanol, zearalenone-14-sulfate, and zearalenone-14-glucoside with human, bovine, porcine, and rat serum albumins were examined, employing fluorescence spectroscopy and affinity chromatography. Zearalanone, zearalanols, and zearalenone-14-sulfate form stable complexes with albumins tested (K= 9.3 x 10(3)to 8.5 x 10(5)L/mol), while the albumin binding of zearalenone-14-glucoside seems to be weak. Zearalenone-14-sulfate formed the most stable complexes with albumins examined. Considerable species differences were observed in the albumin binding of zearalenone metabolites, which may have a role in the interspecies differences regarding the toxicity of zearalenone.
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