Respiratory Variation in Carotid Artery Peak Systolic Velocity Is Unable to Predict Fluid Responsiveness in Spontaneously Breathing Critically Ill Patients When Assessed by Novice Physician Sonologists

Background: Respiratory variation in carotid artery peak systolic velocity (Delta Vpeak) assessed by point-of-care ultrasound (POCUS) has been proposed as a noninvasive means to predict fluid responsiveness. We aimed to evaluate the ability of carotid Delta Vpeak as assessed by novice physician sonologists to predict fluid responsiveness. Methods: This study was conducted in 2 intensive care units. Spontaneously breathing, nonintubated patients with signs of volume depletion were included. Patients with atrial fibrillation/flutter, cardiogenic, obstructive or neurogenic shock, or those for whom further intravenous (IV) fluid administration would be harmful were excluded. Three novice physician sonologists were trained in POCUS assessment of carotid Delta Vpeak. They assessed the carotid Delta Vpeak in study participants prior to the administration of a 500 mL IV fluid bolus. Fluid responsiveness was defined as a >= 10% increase in cardiac index as measured using bioreactance. Results: Eighty-six participants were enrolled, 50 (58.1%) were fluid responders. Carotid Delta Vpeak performed poorly at predicting fluid responsiveness. Test characteristics for the optimum carotid Delta Vpeak of 8.0% were: area under the receiver operating curve = 0.61 (95% CI: 0.48-0.73), sensitivity = 72.0% (95% CI: 58.3-82.56), specificity = 50.0% (95% CI: 34.5-65.5). Conclusions: Novice physician sonologists using POCUS are unable to predict fluid responsiveness using carotid Delta Vpeak. Until further research identifies key limiting factors, clinicians should use caution directing IV fluid resuscitation using carotid Delta Vpeak.

Automated summary

Assessment of carotid Delta Vpeak using POCUS by novice physician sonologists did not effectively predict fluid responsiveness. Clinicians should use caution in directing IV fluid resuscitation based on carotid Delta Vpeak until further research identifies key limiting factors.