期刊
FRONTIERS IN IMMUNOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.01181
关键词
vaccine; genomics; transcriptomics; vaccine development; genetics
类别
资金
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [U01AI089859, R01AI132348, R37AI048793, R01AI033144, R01AI121054, R01AI138965, R01AI127365, 75N93019C00052, R01AI145870, 75N93019C0051, P01AI097092, 75D30119C06088]
The development of vaccines, which prime the immune system to respond to future infections, has led to global declines in morbidity and mortality from dreadful infectious communicable diseases. However, many pathogens of public health importance are highly complex and/or rapidly evolving, posing unique challenges to vaccine development. Several of these challenges include an incomplete understanding of how immunity develops, host and pathogen genetic variability, and an increased societal skepticism regarding vaccine safety. In particular, new high-dimensional omics technologies, aided by bioinformatics, are driving new vaccine development (vaccinomics). Informed by recent insights into pathogen biology, host genetic diversity, and immunology, the increasing use of genomic approaches is leading to new models and understanding of host immune system responses that may provide solutions in the rapid development of novel vaccine candidates.
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