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Darwyn Kobasa et al.
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Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients:: relation to the acute lung injury and pathogenesis of SARS
L. He et al.
JOURNAL OF PATHOLOGY (2006)
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
Ganesh Suntharalingam et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release
Wei Lu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Characterization of the reconstructed 1918 Spanish influenza pandemic virus
TM Tumpey et al.
SCIENCE (2005)
Current concepts - Avian influenza A (H5N1) infection in humans
H Beigel et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Structure of SARS coronavirus spike receptor-binding domain complexed with receptor
F Li et al.
SCIENCE (2005)
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury
K Kuba et al.
NATURE MEDICINE (2005)
Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection
N Schmitz et al.
JOURNAL OF VIROLOGY (2005)
Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry
G Simmons et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1β-induced IL-6 expression
MA Olman et al.
JOURNAL OF IMMUNOLOGY (2004)
Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome - A preliminary study
MR Loutfy et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)
The impact of antithymocyte globulin on short-term toxicity after allogeneic stem cell transplantation
R Pihusch et al.
BONE MARROW TRANSPLANTATION (2002)
Cytokine balance in the lungs of patients with acute respiratory distress syndrome
WY Park et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)
Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis
M Kolb et al.
JOURNAL OF CLINICAL INVESTIGATION (2001)