期刊
FRONTIERS IN IMMUNOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.01387
关键词
NF-kappa B signaling pathway; Helicobacter pylori; microbiota; gastric cancer; colorectal cancer
类别
资金
- National Natural Science Foundation of China [81900500, 81670507, 81870395]
- Education Department of Jiangxi Province [GJJ180115]
- Jiangxi Provincial Department of Science Technology [20192BAB215006]
Gastrointestinal (GI) cancers, especially gastric cancer and colorectal cancer (CRC), represent a major global health burden. A large population of microorganisms residing in the GI tract regulate physiological processes, such as the immune response, metabolic balance, and homeostasis. Accumulating evidence has revealed the alteration of microbial communities in GI tumorigenesis. Experimental studies in cell lines and animal models showed the functional roles and molecular mechanisms of several bacteria in GI cancers, includingHelicobacter pyloriin gastric cancer as well asFusobacterium nucleatum, Escherichia coli, Peptostreptococcus anaerobius, andBacteroides fragilisin CRC. The transcriptional factor NF-kappa B plays a crucial role in the host response to microbial infection through orchestrating innate and adaptive immune functions. Moreover, NF-kappa B activity is linked to GI cancer initiation and development through its induction of chronic inflammation, cellular transformation and proliferation. Here, we provide an overview and discussion of modulation of the NF-kappa B signaling pathway by microbiota, especially infectious bacteria, in GI tumorigenesis, with a major focus on gastric cancer and CRC.
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