期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
卷 7, 期 10, 页码 746-752出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.estlett.0c00478
关键词
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资金
- National Natural Science Foundation of China [21190051, 41421064, 41121004]
- Ministry of Science and Technology of China [2015CB553401]
Ambient particulate matter (PM) is often used as a proxy of personal exposure in epidemiological studies of PMinduced health effects, yet whether this proxy biases the estimates of health effects is still unknown. On the basis of a panel study in Beijing, China, we investigated the dependence of 24 h personal exposure concentration to fine particles (PM2.5) and its carbonaceous components on the corresponding 24 h ambient concentration. The associated changes in inflammatory biomarkers with personal and ambient exposure were further examined using linear mixed-effect models. At ambient PM2.5 levels of <25 mu g m(-3), personal exposure to PM2.5 was often several times higher, with a median personal/ambient ratio of similar to 3. The ratio declined with an increase in ambient concentration, approaching similar to 1 at ambient PM2.5 levels of >75 mu g m(-3). Similar trends were also observed for organic carbon and elemental carbon. Personal exposures were significantly associated with both respiratory and systemic inflammatory biomarkers, such as fractional exhaled nitric oxide and white blood cell count. When ambient data were used, the association with systemic inflammation weakened. Our findings imply that the use of the ambient pollutant concentration as a proxy for personal exposure may be inaccurate and could bias the estimates of PM-induced health effects.
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