期刊
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
卷 21, 期 3, 页码 561-565出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871530320666200801033106
关键词
Autoimmune polyendocrine syndrome; pulmonary arterial hypertension; hypothyroidism; hypoadrenalism; diabetes mellitus
A 24-year-old female with autoimmune polyendocrine syndrome type 2 presented with a variety of symptoms including acute renal failure, melanoderma, hyponatremia, hyperkalemia, heart failure, and pulmonary arterial hypertension. The treatment process requires comprehensive consideration of multiple conditions.
A 24-years old female was admitted for acute renal failure, melanoderma, hyponatremia, and hyperkalemia. The clinical suspicion of Addison's disease was confirmed by laboratory test and the appropriate replacement therapy with corticosteroids and fludrocortisone was started. In the mean-time primary hypothyroidism and diabetes mellitus type 1 were disclosed and treated, thus fulfilling a diagnosis of autoimmune polyendocrine syndrome type 2. Eighteen months later she was admitted for right-sided heart failure. The work-up allowed to diagnose pulmonary arterial hypertension. Here, we report the clinical course and discuss the putative link between these two rare diseases.
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