期刊
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
卷 20, 期 9, 页码 1478-1487出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871530320666200604160614
关键词
Inflammation; menopause; estrogen; osteoporosis; oxidative stress; review
资金
- National University of Malaysia, Kuala Lampur, Malaysia [GUP-2017-012]
Osteoporosis is one of the major health issues associated with menopause-related estrogen deficiency. Various reports suggest that the hormonal changes related to menopausal transition may lead to the derangement of redox homeostasis and ultimately oxidative stress. Estrogen deficiency and oxidative stress may enhance the expression of genes involved in inflammation. All these factors may contribute, in synerey, to the development of postmenopausal osteoporosis. Previous studies suggest that estrogen may act as an antioxidant to protect the bone against oxidative stress, and as an anti-inflammatory agent in suppressing pro-inflammatory and pro-osteoclastic cytokines. Thus, the focus of the current review is to examine the relationship between estrogen deficiency, oxidative stress and inflammation, and the impacts of these phenomena on skeletal health in postmenopausal Women.
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