期刊
ACS INFECTIOUS DISEASES
卷 6, 期 9, 页码 2337-2354出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsinfecdis.0c00384
关键词
antimicrobial resistance; periplasm; antimicrobial target; Gram-negative bacterium; inhibitor; efflux pump; chaperone; virulence
资金
- NIH [1R56AI137020, 1R21AI142063-01]
- NSF [CHE-1709381]
Antibiotic resistance has emerged as a serious threat to global public health in recent years. Lack of novel antimicrobials, especially new classes of compounds, further aggravates the situation. For Gram-negative bacteria, their double layered cell envelope and an array of efflux pumps act as formidable barriers for antimicrobials to penetrate. While cytoplasmic targets are hard to reach, proteins in the periplasm are clearly more accessible, as the drug only needs to breach the outer membrane. In this review, we summarized recent efforts on the validation and testing of periplasmic proteins as potential antimicrobial targets and the development of related inhibitors that either inhibit the growth of a bacterial pathogen or reduce its virulence during interaction with host cells. We conclude that the periplasm contains a promising pool of novel antimicrobial targets that should be scrutinized more closely for the development of effective treatment against multidrug-resistant Gram-negative bacteria.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据