期刊
NANOTECHNOLOGY REVIEWS
卷 9, 期 1, 页码 385-395出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/ntrev-2020-0028
关键词
adipose tissue reconstruction; biomaterial; plastic surgery
类别
资金
- National Key Research and Development Program of China [2018YFC1106800]
- National Natural Science Foundation of China [31971251, 81871574]
- Sichuan Province Science & Technology Department Projects [2016CZYD0004, 2017SZ0001, 2018GZ0142, 2019YFH0079]
- Research Foundation for Young Teachers of Sichuan University [2018SCUH0017]
- 111 Project [B16033]
Adipose tissue reconstruction is an important technique for soft tissue defects caused by facial plastic surgery and trauma. Adipose tissue reconstruction can be repaired by fat transplantation and biomaterial filling, but there are some problems in fat transplantation, such as second operation and limited resources. The application of advanced artificial biomaterials is a promising strategy. In this paper, injectable biomaterials and three-dimensional (3D) tissue-engineered scaffold materials for adipose tissue reconstruction in plastic surgery are reviewed. Injectable biomaterials include natural biomaterials and artificial biomaterials, which generally have problems such as high absorptivity of fillers, repeated injection, and rejection. In recent years, the technology of new 3D tissue-engineering scaffold materials with adipose-derived stem cells (ADSCs) and porous scaffold as the core has made good progress in fat reconstruction, which is expected to solve the current problem of clinical adipose tissue reconstruction, and various biomaterials preparation technology and transformation research also provide the basis for clinical transformation of fat tissue reconstruction.
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