期刊
NANOMATERIALS
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/nano10081543
关键词
modified CeO(2)NPs; oxygen vacancy; photocatalytic degradation; scanning transmission X-ray microscopy; toxicity; cell penetration
类别
资金
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2020R1F1A1049280]
- MSIT
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [NRF-2019R1F1A1058695]
- Canada Foundation for Innovation (CFI)
- Natural Sciences and Engineering Research Council (NSERC)
- National Research Council (NRC)
- Canadian Institutes of Health Research (CIHR)
- Government of Saskatchewan
- University of Saskatchewan
- PAL
- National Research Foundation of Korea [2020R1F1A1049280] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We demonstrated that Fe/Cr doped and pH-modified CeO(2)nanoparticles (NPs) exhibit enhanced photocatalytic performance as compared to bare CeO(2)NPs, using photocatalytic degradation. To assess the toxicity level of these double-modified CeO(2)NPs on the human skin, they were introduced into HaCaT cells. The results of our conventional cellular toxicity assays (neutral red uptake and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide for assays) indicated that Cr@CeO(x)NPs prompt severe negative effects on the viability of human cells. Moreover, the results obtained by scanning transmission X-ray microscopy and bio-transmission electron microscope analysis showed that most of the NPs were localized outside the nucleus of the cells. Thus, serious genetic toxicity was unlikely. Overall, this study highlights the need to prevent the development of Cr@CeOxNP toxicity. Moreover, further research should aim to improve the photocatalytic properties and activity of these NPs while accounting for their stability issues.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据