期刊
NANOMATERIALS
卷 10, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/nano10071351
关键词
photodynamic therapy; bladder cancer; photosensitizers; Au@TNA nanoparticles; phototoxicity; photomedicine
类别
资金
- Ministry of Science and Technology, Taiwan [MOST 107-2113-M-153-002-, 108-2113-M-153-001-, 108-2622-M-006-001-CC1]
- Taipei City Hospital (TCH)
- Department of Health, Taipei City Government (TCH) [10801-62-001, 10901-62-001, 10901-62-006]
Photodynamic therapy (PDT) is a promising treatment for malignancy. However, the low molecular solubility of photosensitizers (PSs) with a low accumulation at borderline malignant potential lesions results in the tardy and ineffective management of recurrent urothelial carcinoma. Herein, we used tannic acid (TNA), a green precursor, to reduce HAuCl(4)in order to generate Au@TNA core-shell nanoparticles. The photosensitizer methylene blue (MB) was subsequently adsorbed onto the surface of the Au@TNA nanoparticles, leading to the incorporation of a PS within the organic shell of the Au nanoparticle nanosupport, denoted as Au@TNA@MB nanoparticles (NPs). By modifying the surface of the Au@TNA@MB NPs with the ligand folate acid (FA) using NH2-PEG-NH(2)as a linker, we demonstrated that the targeted delivery strategy achieved a high accumulation of PSs in cancer cells. The cell viability of T24 cells decreased to 87.1%, 57.1%, and 26.6% upon treatment with 10 ppm([Au])Au@TNA/MB NPs after 45 min, 2 h, and 4 h of incubation, respectively. We also applied the same targeted PDT treatment to normal urothelial SV-HUC-1 cells and observed minor phototoxicity, indicating that this safe photomedicine shows promise for applications aiming to achieve the local depletion of cancer sites without side effects.
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