期刊
NANOMATERIALS
卷 10, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/nano10071366
关键词
alpha-emitters; radiopharmaceuticals; nanoparticles; nanomedicine; targeted therapy; tumour
类别
资金
- National Science Centre [SONATA 2018/31/D/ST4/01488, OPUS 2016/21/B/ST4/02133]
- European Social Fund [POWR.03.02.00-00-I009/17-00]
Recent advances in the field of nanotechnology application in nuclear medicine offer the promise of better therapeutic options. In recent years, increasing efforts have been made on developing nanoconstructs that can be used as carriers for immobilising alpha (alpha)-emitters in targeted drug delivery. In this publication, we provide a comprehensive overview of available information on functional nanomaterials for targeted alpha therapy. The first section describes why nanoconstructs are used for the synthesis of alpha-emitting radiopharmaceuticals. Next, we present the synthesis and summarise the recent studies demonstrating therapeutic applications of alpha-emitting labelled radiobioconjugates in targeted therapy. Finally, future prospects and the emerging possibility of therapeutic application of radiolabelled nanomaterials are discussed.
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