期刊
MULTIPLE SCLEROSIS AND RELATED DISORDERS
卷 42, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.msard.2020.102148
关键词
EDSS; Registries; Patient reported outcome; Self-report; Proxy measure
资金
- Swiss Multiple Sclerosis Society
Background: Clinician-assessed Expanded Disease Status Scale (EDSS) is gold standard in clinical investigations but normally unavailable in population-based, patient-centred MS-studies. Our objective was to develop a selfreported gait measure reflecting EDSS-categories. Methods: We developed the self-reported disability status scale (SRDSS) with three categories (<= 3.5, 4-6.5, >= 7) based on three mobility-related questions. The SRDSS was determined for 173 persons with MS and validated against clinical EDSS to calculate sensitivity and specificity. Results: Accuracy was 88.4% (153 correctly classified) and weighted kappa 0.73 (0.62-0.84). Sensitivity/specificity-pairs were 94.5%/77.8%, 69.0%/94.7% and 100%/98.2% for SRDSS <= 3.5, 4-6.5 and >= 7, respectively. Conclusions: Self-reported SRDSS approximates EDSS-categories well and fosters comparability between clinical and population-based studies.
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