期刊
JOURNAL OF IMMUNOLOGY RESEARCH
卷 2020, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2020/5692829
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资金
- Instituto Mexicano del Seguro Social projects of the Found Health Research [FIS/IMSS/PROT/G13/1221, FIS/IMSS/PROT/G16/1588]
Interleukin- (IL-) 17 is increased in acute myocardial infarction (AMI) and plays a key role in inflammatory diseases through its involvement in the activation of leukocytes. Here, we describe for the first time the effect of IL-17 in the migration and activation of monocyte subsets in patients during ST-segment elevation myocardial infarction (STEMI) and post-STEMI. We analyzed the circulating levels of IL-17 in patient plasma. A gradual increase in IL-17 was found in STEMI and post-STEMI patients. Additionally, IL-17 had a powerful effect on the recruitment of CD14(++)CD16(+)/CD14(+)CD16(++)monocytes derived from patients post-STEMI compared with the monocytes from patients with STEMI, suggesting that IL-17 recruits monocytes with inflammatory activity post-STEMI. Furthermore, IL-17 increased the expression of TLR4 on CD14(+)CD16(-)and CD14(++)CD16(+)/CD14(+)CD16(++)monocytes post-STEMI and might enhance the response to danger-associated molecular patterns post-STEMI. Moreover, IL-17 induced secretion of IL-6 from CD14(++)CD16(-)and CD14(++)CD16(+)/CD14(+)CD16(++)monocytes both in STEMI and in post-STEMI, which indicates that IL-17 has an effect on the secretion of proinflammatory cytokines from monocytes during STEMI and post-STEMI. Overall, we demonstrate that in STEMI and post-STEMI, IL-17 is increased and induces the migration and activation of monocyte subsets, possibly contributing to the inflammatory response through TLR4 and IL-6 secretion.
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