Negative Correlation Between Functional Connectivity and Small-Worldness in the Alpha Frequency Band of a Healthy Brain

The aim of the study was to analyze the relationship between resting state electroencephalographic (EEG) alpha functional connectivity (FC) and small-world organization. For that purpose, Pearson correlation was calculated between FC and small-worldness (SW). Three undirected FC measures were used: magnitude-squared coherence (MSC), imaginary part of coherency (ICOH), and synchronization likelihood (SL). As a result, statistically significant negative correlation occurred between FC and SW for all three FC measures. Small-worldness of MSC and SL were mostly above 1, but lower than 1 for ICOH, suggesting that functional EEG networks did not have small-world properties. Based on the results of the current study, we suggest that decreased alpha small-world organization is compensated with increased connectivity of alpha oscillations in a healthy brain.