期刊
FRONTIERS IN NEUROSCIENCE
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2020.00576
关键词
theta burst stimulation; accelerated; motor cortex; cortical plasticity; stimulation interval
资金
- Key Projects of Shanghai Science and Technology on Biomedicine [18411962300]
- Shanghai Health and Family Planning Commission project [201840225]
- Shanghai Municipal Key Clinical Specialty [shslczdzk02702]
Objective The study aims to investigate the after-effect of three sessions of intermittent theta-burst stimulation (iTBS) on motor cortical excitability. The iTBS was induced over the primary motor cortex (M1) at different time intervals. Methods The study has a crossover design. Sixteen participants were assigned to three groups and received different accelerated iTBS (aiTBS) protocols during each visit: (1) three continuous sessions with no interval (iTBS18000); (2) three iTBS sessions with 10-min intervals (iTBS600 x 3*10); and (3) three iTBS sessions with 30-min intervals (iTBS600 x 3*30). As washout period, each visit is separated by at least 7 days. We measured the motor cortical excitability changes and intracortical inhibition. Results A dose of 1,800 pulses of aiTBS per day is tolerable. The iTBS1800 led to a reduced cortical excitability; whereas iTBS600 x 3*10 and iTBS600 x 3*30 enhanced cortical excitability to a differential extent. After a total dose of 1,800 pulses, iTBS600 x 3*30 exhibited the longer effect and highest percentage of individuals with enhanced cortical excitability. Conclusion The results suggest that aiTBS protocols at different time intervals result in different motor cortical excitability after-effects.
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