期刊
CANCER MEDICINE
卷 9, 期 19, 页码 6909-6922出版社
WILEY
DOI: 10.1002/cam4.3379
关键词
biomarker; diagnostic; exosomal miRNA; lung cancer; non-coding RNA; prognostic
类别
资金
- Key Programs for Research and Development of Anhui Province [1704a0802153]
- Fundamental Research Funds for the Central Universities [WK911000057]
- Project of the Science and Technology Innovation of Anhui province [2017070802D146]
More and more studies report that exosomes released by various cells can serve as a medium for information exchange between different cells. Through a deep understanding of the physical and chemical properties of exosomes, the researchers revealed a more precise molecular mechanism of its participation in the process of intercellular communication. In particular, microRNA (miRNA) is found inside exosomes, as well as long noncoding RNA (lncRNA). Extensive evidence indicates that exosomal miRNAs participates in the occurrence and development of lung cancer and plays a variety of roles. Therefore, the release of RNA-containing exosomes in many different kinds of body fluids has caused widespread interest among researchers. In this review, we report evidence from human studies involving miRNAs and other ncRNAs in exosomes associated with lung cancer as diagnostic and prognostic markers. Currently, there is a small amount of evidence that exosomal miRNAs can be used as early diagnosis and prognostic markers for lung cancer, and their exact role in lung cancer patients still needs further study.
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