期刊
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
卷 128, 期 6, 页码 1421-1425出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13813455.2020.1773861
关键词
The fat mass and obesity associated; FTO; body fat; polymorphism
资金
- Student Research Committee of Guilan University of Medical Sciences, Rasht, Iran [98050510]
This meta-analysis investigated the association between the rs9939609 FTO gene polymorphism and body fat percentage (BF%). The results showed that carriers of the A allele of FTO rs9939609 polymorphism had higher BF%.
This meta-analysis aimed to investigate the association of the rs9939609 FTO gene polymorphism and body fat percentage (BF%). To the best of our knowledge, this study is the first meta-analysis to evaluate the relationship between FTO rs9939609 polymorphism and BF%. We searched PubMed, Web of science, Scopus and Embase to identify studies investigating the relations between the rs9939609 FTO gene polymorphism and BF%. Studies that meet inclusion criteria were collected for the final analysis. There was significant differences in the level of BF% between different genotypes of FTO rs9939609 polymorphism, and the carriers of the A allele of FTO rs9939609 polymorphism had higher BF%. The association was significant between carriers of TT genotype compared to carriers of AA (p = .007) and AT genotypes (p = .04), but not between AT and AA genotypes. This study identified that the carriers of the A allele of FTO rs9939609 polymorphism have higher BF%.
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