期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 142, 期 -, 页码 165-172出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2016.02.050
关键词
Electrospinning; Scaffold; Nanofiber; Tissue engineering; Superelastic
资金
- National Natural Science Foundation of China [31470941, 31271035]
- Science and Technology Commission of Shanghai Municipality [15JC1490100, 15441905100]
- Ph.D. Programs Foundation of Ministry of Education of China [20130075110005]
- light of textile project [J201404]
- Fundamental Research Funds for the Central Universities [CUSF-DH-D-2016021]
- Yantai Double Hundred Talent Plan
- Deanship of Scientific Research at King Saud University through the research group [RGP-201]
Fabrication of 3D scaffold to mimic the nanofibrous structure of the nature extracellular matrix (ECM) with appropriate mechanical properties and excellent biocompatibility, remain an important technical challenge in tissue engineering. The present study reports the strategy to fabricate a 3D nanofibrous scaffold with similar structure to collagen in ECM by combining electrospinning and freeze-drying technique. With the technique reported here, a nanofibrous structure scaffold with hydrophilic and superabsorbent properties can be readily prepared by Gelatin and Polylactic acid (PLA). In wet state the scaffold also shows a super-elastic property, which could bear a compressive strain as high as 80% and recovers its original shape afterwards. Moreover, after 6 days of culture, L-929 cells grow, proliferate and infiltrated into the scaffold. The results suggest that this 3D nanofibrous scaffold would be promising for varied field of tissue engineering application. (C) 2016 Elsevier B.V. All rights reserved.
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