期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 148, 期 -, 页码 317-323出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2016.09.002
关键词
Gold nanoparticles; Photochemically-assisted synthesis; Photochemical reduction; Biocompatible nanoparticles; Branched polyethyleimine
资金
- CNPq [308038/2012-6]
- FAP-DF [0193.000829/2015]
- CAPES
This contribution describes the photochemically-assisted synthesis of aqueous colloidal suspensions of non-toxic and biocompatible spherical gold nanoparticles stabilized by branched polyethylenimine, or else Au-np-PEI. The method consists on 30 min of photoexcitation (254 nm, 16W) at room temperature of an aqueous diluted solution of chloroauric acid (HAuCl4) containing PEI. While the UV irradiation forms the [Au(3+)Cl4-]* excited species that succesively transforms into zero valent Au, PEI controls the nucleation step of nanoparticles formation. Varying the PEI to Au molar ratio permits one to tune the size of nanoparticles between 100 nm to 8 nm. The obtained colloidal suspensions display an intense plasmonic absorption band at 520-530nm and positive zeta potentials greater than +20 mV. The cells viability for in vitro tests performed with human connective tissues and human breast adenocarcinoma (MCF-7) cell lines is over 80% and 90%, respectively, when they are incubated with Au-np-PEI formulations (25 mu gmL(-1)). The present photochemically-assisted synthesis is advantageous because it is fast and does not require for either hazardous or cytotoxic reductant agents and additional purification procedures. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据