期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 143, 期 -, 页码 447-454出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2016.03.073
关键词
Titanium dioxide; Drug delivery systems; Ibuprofen; Gentamicin; Anodization
资金
- National Science Centre, Poland [2013/11/N/ST5/01640]
- project Interdisciplinary PhD Studies Molecular sciences for medicine
- European Social Fund within the Human Capital Operational Programme
- Marian Smoluchowski Krakow Scientific Consortium Matter - Energy - Future
Nanoporous anodic titanium dioxide (ATO) layers on Ti foil were prepared via a three step anodization process in an electrolyte based on an ethylene glycol solution with fluoride ions. Some of the ATO samples were heat-treated in order to achieve two different crystallographic structures - anatase (400 degrees C) and a mixture of anatase and rutile (600 degrees C). The structural and morphological characterizations of ATO layers were performed using a field emission scanning electron microscope (SEM). The hydrophilicity of ATO layers was determined with contact angle measurements using distilled water. Ibuprofen and gentamicin were loaded effectively inside the ATO nanopores. Afterwards, an in vitro drug release was conducted for 24h under a static and dynamic flow conditions in a phosphate buffer solution at 37 degrees C. The drug concentrations were determined using UV-Vis spectrophotometry. The absorbance of ibuprofen was measured directly at 222 nm, whether gentamicin was determined as a complex with silver nanoparticles (Ag NPs) at 394 nm. Both compounds exhibited long term release profiles, despite the ATO structure. A new release model, based on the desorption of the drug from the ATO top surface followed by the desorption and diffusion of the drug from the nanopores, was derived. The proposed release model was fitted to the experimental drug release profiles, and kinetic parameters were calculated. (C) 2016 Elsevier B.V. All rights reserved.
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