期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 142, 期 -, 页码 392-399出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2016.03.007
关键词
Silver nanoparticle; Antibiotic; Resistant bacteria; Synergism; Cytotoxicity
资金
- Ministry of Education, Youth and Sports of the Czech Republic [LO1305]
- Czech Science Foundation [15-22248S]
- Ministry of Health of the Czech Republic [AZV VES 15-27726A]
- Internal Grants of Palacky University in Olomouc [IGA_PrF_2015_022, IGA_LF_2015_035]
Bacterial resistance to conventional antibiotics is currently one of the most important healthcare issues, and has serious negative impacts on medical practice. This study presents a potential solution to this problem, using the strong synergistic effects of antibiotics combined with silver nanoparticles (NPs). Silver NPs inhibit bacterial growth via a multilevel mode of antibacterial action at concentrations ranging from a few ppm to tens of ppm. Silver NPs strongly enhanced antibacterial activity against multiresistant, B-lactamase and carbapenemase-producing Enterobacteriaceae when combined with the following antibiotics: cefotaxime, ceftazidime, meropenem, ciprofloxacin and gentamicin. All the antibiotics, when combined with silver NPs, showed enhanced antibacterial activity at concentrations far below the minimum inhibitory concentrations (tenths to hundredths of one ppm) of individual antibiotics and silver NPs. The enhanced activity of antibiotics combined with silver NPs, especially meropenem, was weaker against non-resistant bacteria than against resistant bacteria. The double disk synergy test showed that bacteria produced no B-lactamase when treated with antibiotics combined with silver NPs. Low silver concentrations were required for effective enhancement of antibacterial activity against multiresistant bacteria. These low silver concentrations showed no cytotoxic effect towards mammalian cells, an important feature for potential medical applications. (C) 2016 Elsevier B.V. All rights reserved.
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