期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 148, 期 -, 页码 557-565出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2016.09.035
关键词
Electrospinning; Carbon black; Nerve regeneration; Electroactive materials; 4D scaffolds
A porous shape memory scaffold with both biomimetic structures and electrical conductivity properties is highly promising for nerve tissue engineering applications. In this study, a new shape memory polyurethane polymer which consists of inorganic polydimethylsiloxane (PDMS) segments with organic poly(epsilon-caprolactone) (PCL) segments was synthesized. Based on this poly(PCL/PDMS urethane), a series of electrically conductive nanofibers were electrospun by incorporating different amounts of carbon-black. Our results showed that after adding carbon black into nanofibers, the fiber diameters increased from 399 +/- 76 to 619 +/- 138 nm, the crystallinity decreased from 33 to 25% and the resistivity reduced from 3.6 GO/mm to 1.8 k Omega/mm. Carbon black did not significantly influence the shape memory properties of the resulting nanofibers, and all the composite nanofibers exhibited decent shape recovery ratios of >90% and shape fixity ratios of >82% even after 5 thermo-mechanical cycles. PC12 cells were cultured on the shape memory nanofibers and the composite scaffolds showed good biocompatibility by promoting cell cell interactions. Our study demonstrated that the poly(PCL/PDMS urethane)/carbon-black nanofibers with shape memory properties could be potentially used as smart 4-dimensional (4D) scaffolds for nerve tissue regeneration. (C) 2016 Elsevier B.V. All rights reserved.
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