期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 140, 期 -, 页码 246-253出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2015.12.019
关键词
Solid lipid nanoparticle; Doxorubicin; alpha-Tocopherol succinate; Cancer; Cytotoxicity
资金
- NIH [1R03TW008709]
- Minas Gerais State Agency for Research and Development (FAPEMIG, Brazil)
- CAPES
- CNPq
This work aimed to develop solid lipid nanoparticles (SLN) co-loaded with doxorubicin and alpha-tocopheryl succinate (TS), a succinic acid ester of alpha-tocopherol that exhibits anticancer actions, evaluating the influence of TS on drug encapsulation efficiency. The SLN were characterized for size, zeta potential, entrapment efficiency (EE), and drug release. Studies of in vitro anticancer activity were also conducted. The EE was significantly improved from 30 +/- 1% to 96 +/- 2% for SLN without and with TS at 0.4%, respectively. In contrast, a reduction in particle size from 298 +/- 1 to 79 +/- 1 nm was observed for SLN without and with TS respectively. The doxorubicin release data show that SLN provide a controlled drug release. The in vitro studies showed higher cytotoxicity for doxorubicin-TS-loaded SLN than for free doxorubicin in breast cancer cells. These findings suggest that TS-doxorubicin-loaded SLN is a promising alternative for the treatment of cancer. (C) 2015 Elsevier B.V. All rights reserved.
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