期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 140, 期 -, 页码 161-168出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2015.12.040
关键词
Core-shell mesoporous silica; Curcumin; Caco-2 cells; Bioavailability
资金
- French Ministry of Higher Education (MERS)
- French National Scientific Centre (CNRS)
- Region Lorraine
- French Ministry of Higher Education
Newly designed microcapsules (MC) combining a core of solid lipid nanoparticle (SLN) and a mesoporous silica shell have been developed and explored as oral delivery system of curcumin (CU). CU-loaded MC (MC-CU) are 2 mu m sized and have a mesoporous silica shell of 0.3 mu m thickness with a wormlike structure as characterized by small angle X-ray scattering (SAXS), nitrogen adsorption/desorption and transmission electron microscopy (TEM) measurements. It was found that SLN acts as reservoir of curcumin while the mesoporous shell insures the protection and the controlled release of the drug. MC-CU displayed a pH-dependent in vitro release profile with marked drug retention at pH 2.8. Neutral red uptake assay together with confocal laser scanning microscopy (CLSM) showed a good cell tolerance to MC-CU at relatively high concentration of inert materials. Besides, the cell-uptake test revealed that fluorescent-MC were well internalized into Caco-2 cells, confirming the possibility to use MC for gut cells targeting. These findings suggest that organic core-silica shell microcapsules are promising drug delivery systems with enhanced bioavailability for poorly soluble drugs. (C) 2015 Elsevier B.V. All rights reserved.
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