期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 143, 期 -, 页码 148-155出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2016.03.029
关键词
Titanium dioxide; Surface modification; Endocytosis
资金
- National Natural Science Foundation of China [11574056, 61575046, 61505032]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education of the People's Republic of China
- Shanghai Pujiang Program [13PJ1400300]
- Talents Training Program (Zhuo-Xue) of Fudan University
Titanium dioxide nanoparticles (TiO2 NPs) have a potential in the field of biological application. However, its poor dispersibility in water hampered its applications. In this study, 3-phosphonopropionic acid and 3-aminopropyl-triethoxysilane were respectively used for surface modification on TiO2 NPs with negative and positive surface charges (denoted as TiO2-COOH and TiO2-NH2). Zeta potentials of the prepared samples with high absolute value demonstrate the great improvement in their dispersibility. In terms of viability experiment, both TiO2-COOH and TiO2-NH2 showed low cytotoxicity. The cellular uptake efficiency and the uptake pathways of TiO2-COOH and TiO2-NH2 for cancer cells were studied. The exocytosis of TiO2-NH2 was also observed in the experiment. (C) 2016 Elsevier B.V. All rights reserved.
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