期刊
JOURNAL OF THE AMERICAN HEART ASSOCIATION
卷 9, 期 16, 页码 -出版社
WILEY
DOI: 10.1161/JAHA.119.015229
关键词
APOE genotype; brain aging; magnetic resonance imaging; perivascular spaces; vascular risk factors
资金
- Swedish Ministry of Health and Social Affairs
- Stockholm County Council
- Stockholm Municipality
- Swedish Research Council
- Swedish Research Council (VR) [2015-02531, 2016-06658, 2017-05819, 2017-00740]
- Swedish Research Council for Health, Working Life and Welfare (FORTE) [2014-01382]
- Swedish Foundation for International Cooperation in Research and Higher Education (STINT) [CH2019-8320]
- Karolinska Institutet, Stockholm, Sweden
- Forte [2014-01382] Funding Source: Forte
- Swedish Research Council [2017-05819, 2015-02531, 2016-06658, 2017-00740] Funding Source: Swedish Research Council
Background Evidence suggests that enlarged perivascular spaces (PVSs) may represent a marker for cerebral small-vessel disease. We investigated whether vascular risk factors are correlated with visible PVS in older adults. Methods and Results This population-based study included 530 participants (age >= 60 years) who were free from dementia and functional dependence, derived from the Swedish National study on Aging and Care in Kungsholmen (2001-2003). We collected data on demographics, vascular risk factors, and health conditions through interviews, clinical examinations, laboratory tests, and patient registers. Cerebral PVSs and white matter hyperintensities on magnetic resonance images were visually assessed with semiquantitative visual rating scales. Data were analyzed using the general linear regression models. After controlling for demographics and cardiovascular disease, very high blood pressure (>= 160/100 mm Hg) was significantly associated with global PVS score (beta -coefficient, 1.30; 95% CI, 0.06-2.53) and orthostatic hypotension was associated with PVS score in the basal ganglia (beta -coefficient 0.37; 0.03-0.70), but the associations became non-significant when adjusting for white matter hyperintensity load. Orthostatic hypotension was significantly associated with global and lobar PVS scores in carriers but not in noncarriers of the APOE epsilon 4 allele. Global or regional PVS score was not significantly associated with other traditional vascular risk factors such as smoking, diabetes mellitus, physical inactivity, and overweight or obesity. Conclusions This study provides limited evidence supporting a correlation of magnetic resonance imaging-visible PVS with traditional vascular risk factors in older adults. The association of orthostatic hypotension with lobar PVS among APOE epsilon 4 carriers suggests that lobar PVS may be a marker for amyloid-associated small-vessel disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据