期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 141, 期 -, 页码 623-633出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2016.02.036
关键词
ZnO nanowire; Self-antibacterial effect; Surface modification; Bioluminescent bacteria
资金
- University of Hong Kong Foundation Seeding Fund for Applied Research
- Special Prophase for Key Basic Research of Ministry of Science and Technology of China (973 Program) [2014CB660809]
- National Natural Science Foundation of China [51422102, 81271715, 31370957]
To prevent the attachment of bacteria to implant surfaces, the 10 zinc oxide nanowire-coating has been successfully developed on material surfaces by using a custom-made hydrothermal approach. The chemical nature, surface topography and wettability of spike-like 1D ZnO nanowire-coating are comprehensively investigated. The anti-adhesive and antimicrobial properties of 1D nanowire-coating are tested against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli by using in vitro live/dead staining and scanning electron microscopy. We find that the adhesion of bacteria can be reduced via the special spike-like topography and that the release of Zn2+ ions can help suppress the growth of attached bacteria. Furthermore, the antimicrobial effect is also evaluated under in vivo conditions by using a rat model infected with bioluminescent S. aureus. The amount of live bacteria in the rat implanted with a nanowire-coated sample is less than that of the control at various time points. Hence, it is believed that the nanowire-coated material is promising for application in orthopaedic implantation after the long-term animal studies have been completed. (C) 2016 Published by Elsevier B.V.
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