期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 141, 期 -, 页码 450-457出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2016.02.002
关键词
PLA; DDAB; CTAB; Ocular; Size; Surface charge; Shape; Stability; Sustained release
资金
- PO-FESR SICILIA Linea d'intervento [4.1.2.A]
- MIUR-FIR (Italy)
Polymeric and hybrid aqueous-core nanocapsules were prepared using a low energy organic-solvent free procedure as innovative nanodevices for the ophthalmic delivery of melatonin. In order to evaluate how different cationic lipids could affect the main properties of the nanodevices, we focused our attention on mean particles size, surface charge, shape and stability (the 4S). The results of our study confirmed the hypothesis that the coating material differently affects the overall nanoparticles properties, above all in terms of morphology: in particular, the cationic lipid dimethyldioctadecylammonium bromide allows the formation of very stable well-defined nanocapsules with non-spherical shape with sustained and prolonged drug release, thus representing a great advantage in ophthalmic application. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据