期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 139, 期 -, 页码 156-163出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2015.12.001
关键词
Grape seed extract; Silk fibroin; Green electrospinning; Antioxidation
资金
- Natural Science Foundation of Shanghai [12ZR1400300]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
- 111 project [B07024]
Silk fibroin (SF) from Bombyx mori has an excellent biocompatibility and thus be widely applied in the biomedical field. Recently, various SF-based composite nanofibers have been developed for more demanding applications. Additionally, grape seed extract (GSE) has been demonstrated to be powerful on antioxidation. In the present study, we dedicate to fabricate a GSE-loaded SF/polyethylene oxide (PEO) composite nanofiber by green electrospinning. Our results indicated the successful loading of GSE into the SF/PEO composite nanofibers. The introduction of GSE did not affect the morphology of the SF/PEO nanofibers and GSE can be released from the nanofibers with a sustained manner. Furthermore, comparing with the raw SF/PEO nanofibrous mats, the GSE-loaded SF/PEO nanofibrous mats significantly enhanced the proliferation of the skin fibroblasts and also protected them against the damage from tert-butyl hydroperoxide-induced oxidative stress. All these findings suggest a promising potential of this novel GSE-loaded SF/PEO composite nanofibrous mats applied in skin care, tissue regeneration and wound healing. (C) 2015 Elsevier B.V. All rights reserved.
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